Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 16359969
Gene Name IL4
Condition Endometriosis
Association Associated
Population size 35
Population details 35 (15 women with endometriosis, 20 fertile controls)
Sex Female
Associated genes IL-4, IL-10
Other associated phenotypes Endometriosis
Changes in the T-helper cytokine profile and in lymphocyte activation at the systemic and local levels in women with endometriosis.

Fertil Steril. 2005 Dec;84(6):1705-11.

Antsiferova, Yulia S| Sotnikova, Natalia Yu| Posiseeva, Lyubov V| Shor, Artur L

Laboratory of Clinical Immunology, State Research Institute of Maternity and Childhood, Ivanovo, Russia. ivniimid@ivnet.ru

OBJECTIVE: To estimate regulatory cytokine synthesis and lymphocyte activation in the peripheral blood and endometrial tissue of patients with endometriosis. DESIGN: Controlled clinical study. SETTING: Medical center. PATIENT(S): Fifteen women with laparoscopically diagnosed endometriosis; 20 gynecologically healthy women with previously documented fertility (control group). INTERVENTION(S): Peripheral venous blood sampling; laparoscopic collection of ectopic and matched eutopic endometrium. MAIN OUTCOME MEASURE(S): Messenger RNA (mRNA) for interleukin (IL)-2, IL-4, and IL-10 expression in peripheral and endometrium lymphocytes was assessed by real-time reverse transcriptase polymerase chain reaction; intracellular synthesis of these cytokines and lymphocyte phenotype profile were established by flow cytometry. RESULT(S): Both mRNA expression and intracellular synthesis of IL-4 and IL-10 were sharply increased in peripheral lymphocytes. The same changes were observed for IL-4 in ectopic endometrium of women with endometriosis. Simultaneously, elevation of the amount of pan-B cells, CD20+CD5+ B-1 cells, and activated HLA-DR+CD20+ B lymphocytes was observed in endometriosis lesions. Only an enhanced amount of B lymphocytes was seen in eutopic endometrium. CONCLUSION(S): Endometriosis development is accompanied by the activation of a T-helper type 2 immune response at the systemic and local levels. Our results support the hypothesis regarding the autoimmune nature of endometriosis and can explain the high level of autoantibody production in patients with endometriosis.

Mesh Terms: Adult| B-Lymphocyte Subsets/*immunology/metabolism| Cytokines/genetics/*immunology/metabolism| Endometriosis/*immunology/pathology| Endometrium/immunology/pathology| Female| Flow Cytometry| Gene Expression/immunology| Humans| Interleukin-10/genet